These cancers occur most often on the face, lips, and eyelids. Most people with xeroderma pigmentosum develop multiple skin cancers during their lifetime. Without sun protection, about half of children with this condition develop their first skin cancer by age 10. People with xeroderma pigmentosum have a greatly increased risk of developing skin cancer. This combination of features gives the condition its name, xeroderma pigmentosum. ![]() In affected individuals, exposure to sunlight often causes dry skin (xeroderma) and changes in skin coloring (pigmentation). By age 2, almost all children with xeroderma pigmentosum develop freckling of the skin in sun-exposed areas (such as the face, arms, and lips) this type of freckling rarely occurs in young children without the disorder. Other affected children do not get sunburned with minimal sun exposure, but instead tan normally. The sunburn causes redness and blistering that can last for weeks. ![]() Many affected children develop a severe sunburn after spending just a few minutes in the sun. ![]() The signs of xeroderma pigmentosum usually appear in infancy or early childhood. Some affected individuals also have problems involving the nervous system. This condition mostly affects the eyes and areas of skin exposed to the sun. Xeroderma pigmentosum, which is commonly known as XP, is an inherited condition characterized by an extreme sensitivity to ultraviolet (UV) rays from sunlight.
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